ZaZaTick Plus Spot On for Small Dogs
Fipronil 9.8% w/v and (S)-Methoprene 8.8% w/v Solution
6 Tubes of 1.34ml (Do not use on puppies below 8 week of age)
For Medium Dogs 10 - 20 Kgs
AGAINST TICKS, FLEAS AND LIES IN ALL STAGES
LONG ACTING SPOT ON SOLUTION
Fipronil 9.8% w/v
(S)-Methoprene 8.8% w/v
Fipronil belongs to the family of compounds called phenylpyrazole. It acts through the interaction with complexes formed between the chloride channels and their ligands, especially the neurotransmitter GABA (gamma-amino butyric acid), thus blocking the transfer of chloride ions across cell membranes to levels pre and post sybaptic. Fipronil kills fleas within 24 hours, ticks (Dermacentor vatiabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava and Haemaphy- salis campanulata) and lice within 48 hours after application of the product.
The (S)-methoprene is a regulator of insect growth (ROI) belonging to the class of similar juvenile hormone. It inhibits the development of immature stages of insects. By mimicking the action of the juvenile hormone, the compound causes impaired development and death of fleas during their immature stages.
IMPACTS OF POST-ADMINISTRATION OF DRUGS Reported studies showed that absolute bioavailability of fipronil was 9.5 %. The mean maximum concentration (Cmax) was found to be 19 ng/ml in plasma found after 5 days (Tmax). Several studies have found that plasma concentrations were below 1 ng/ml (limit of quantification) at approximately 33 days following topical administration.
Moreover, these studies have found that (S)-methoprene showed very low dermal absorption and the readings of theplasma concentrations were below the limit of quantification (10 ng/ml).
In Dogs, fipronil’s major metabolite that are found on the haircoat of the dog and in the blood stream are known as sulfone derivatives. Fipronilsulfone is found to have produced on the haircoat (mean concentrations < 16% of fipronil during the first month after treatment), while(S)-methoprene is extensively degraded into carbon dioxide. Another compound calledacetate is subsequently incorporated into endogenous materials.
In dogs after administration of the association topically, fipronil is poorly absorbed (11%) with average maximum plasma concentration of approximately 35 ng/ml for fipronil and 55 ng/ml for fipronilsulfone.
In dogs, the plasma fipronil concentrations slowly reached a peak average about 101 hours and decreasing slowly (half-life) by approximately 154 hours, the highest values are observed in males.
Plasma concentrations of (S)-methoprene are generally below the quantification (20 ng/ml) in dogs after topical administration.
The concentrations of fipronil, fipronilsulfone and (S)-methoprene in peeling decreases with time, but are detectable at least 60 days after application in dogs.
Parasites are killed mainly by contact and not by systemic exposure. No pharmacological interference between fipronil and (S)-methoprene was detected.
INDICATION AND DOSAGE
- ZAZA TICK PLUS SPOT ON provides fast, effective and convenient treatment and control of fleas, ticks and chewing lice.
- Treatment and prevention of flea infestation (Ctenocephalides spp) and control of brown dog ticks (Rhipicephalus sanguineus), paralysis tick (Ixodes holocyclus) and biting ice (Trichodectes canis) on dogs.
- ZAZA TICK PLUS SPOT ON has a rapid onset of action and kills re-infections with newly acquired adult fleas for at least one month.
- ZAZA TICK PLUS SPOT ON also prevents the development of flea eggs, larvae and pupae produced by adult fleas acquired for three months in dogs after treatment.
- ZAZA TICK PLUS SPOT ON controls brown dog ticks for up to one month and paralysis ticks for up to two weeks after application in dogs. Daily searching of dog is necessary to minimise the risk of tick paralysis. Searching should continue throughout the paralysis tick season.
- ZAZA TICK PLUS SPOT ON may be used for the treatment and control of Flea Allergy Dermatitis in dogs.
- ZAZA TICK PLUS SPOT ON is used for flea control as it breaks the life cycle on the dog and in its surrounding by killing all stages of fleas.
Recommended Dosage for Dogs
ZAZA TICK PLUS SPOT ON for small dogs
(For use on puppies from 8 weeks of age)
Up to 10 kg
ZAZA TICK PLUS SPOT ON for medium dogs
10 - 20 kg
ZAZA TICK PLUS SPOT ON for large dogs
20 - 40 kg
ZAZA TICK PLUS SPOT ON for extra-large dogs
40 - 60 kg
For Fleas: Monthly application is recommended for dogs. All dogs in a household should be treated at the same time. It is especially important to treat all household dogs if any pet is allergic to fleas (flea allergy dermatitis).
Paralysis Ticks: Two-weekly application in dogs is recommended. ZAZA TICK PLUS SPOT ON provides control of paralysis ticks for up to 2 weeks, use of this product does not guarantee prevention of tick paralysis because ticks are not killed immediately after attachment. Daily searching of dogs is necessary to minimise the risk of tick paralysis. Searching should continue throughout the paralysis tick season, which extends from spring to Autumn, but may be year round in some localised areas.
Brown Dog Tick: Monthly application is recommended in dogs.
Biting Lice: Treat all household dogs at the same time.
Part the hair at back of dog, at the base of the neck between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze gently at one or two spots to empty its contents onto the skin. Care should be taken to avoid excessive wetting of hair during treatment of dogs. Do not allow treated dogs to lick each other or rub against other animals until the application site is dry.
CAUTION: Hazardous to Human.
This product may cause irritation of mucous membranes, skin and eyes. So avoid contact of the product with the mouth, skin or eyes. Dogs or those who have known hypersensitivity to insecticides or alcohol should avoid contact with the drug. Avoid contact of contents with the fingers. If this occurs, wash hands with soap and water. In case of accidental exposure with eyes, rinse with clean water carefully. Do not handle treated dogs and don’t allow children to play with treated dogs until the application site is dry. It is therefore recommended that dogs are not treated in the day but in the early evening and that recently treated dogs are not allowed to sleep with owners, especially children. Do not smoke, drink or eat during application.
SAFETY IN DOGS: For external use only.
ZAZA TICK PLUS SPOT ON is safe for use in dogs and puppies over 8 weeks of age and in breeding, pregnant or lactating bitches. Do not use ZAZA TICK PLUS SPOT ON if you or your pet has a known hypersensitivity to insecticides or alcohol.
Do not use on puppies below 8 weeks of age. Avoid contact with eyes and skin. If product comes in contact with eyes, wash immediately with water. Wash hands after use. Harmful if swallowed. Do not allow children to apply product on per. Avoid contact with treated area until dry.
Method of Application
Read pack insert before use.
Frequency of Application
When used monthly Zaza Tick Plus Spot On completely breaks the flea life cycle and controls
tick and chewing lice infestation. Do not reapply Zaza Tick.
KEEP OUT OF REACH OF CHILDREN. HAZARDOUS TO HUMAN.
PHYSICAL OR CHEMICAL HAZARDS: FLAMMABLE
Keep away from heat and open flame.
Store below 30 C in dark place. Protect from heat.
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not discard the product or empty tubes in ponds, rivers and streams. Securely wrap tube in several layers of newspaper and discard in trash.
NOT FOR HUMAN USE.
FOR ANIMAL TREATMENT ONLY.
FOR EXTERNAL USE ONLY.
FOR THE TREATMENT OF DOGS ONLY.
ZAZA TICK PLUS SPOT ON SOLUTION For Dogs up to 10 kg 1 / 3 / 6 Lami Tubes of 0.67 ml.
(FOR USE ON PUPPIES FROM 8 WEEKS OF AGE)
ZAZA TICK PLUS SPOT ON SOLUTION For Dogs over 10 kg to 20 kg 1 / 3 / 6 Lami Tubes of 1.34 ml.
ZAZA TICK PLUS SPOT ON SOLUTION For Dogs over 20 kg up to 40 kg 1 / 3 / 6 Lami Tubes of 2.68 ml.
ZAZA TICK PLUS SPOT ON SOLUTION For Dogs 40-60 kg 1 / 3 / 6 Lami Tubes of 4.02 ml.